Humber Orangeville was a partnership between the Town of Orangeville and Humber College. Its origins can be traced back to 2004, when the Town approached Humber with a proposal to establish a campus which would serve communities in Dufferin, Wellington, Peel, and Simcoe Counties. In 2005, the Town and College signed a Memorandum of Understanding and the town donated a 28 acre site on Veterans Way for Humber to build a new campus on. In the mean time, Joe Andrews was appointed as Head of Community Relations in Orangeville, and a series of lectures and events were held to promote Humber to the communities.

Building on the new Veterans Way site was delayed, but Humber started offering courses at the Alder Street Recreational Centre in the fall of 2007. Initial course offerings included Police Foundations, Business Administration/Management. Early Childhood Education and Home Renovation were added shortly after. In 2012, plans for development at the Veterans Way say were stalled, and eventually cancelled. Humber continued to operate out of the Alder Street location, until the decision was made in September 2019 to wind-down operations at the campus. The campus closed in June 2021.